Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin.

@article{Oda2009ClockGM,
  title={Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin.},
  author={Akira Oda and Yu Katayose and Shinichi Yabuuchi and Kuniharu Yamamoto and Masamichi Mizuma and Satoru Shirasou and Toru Onogawa and Hideo Ohtsuka and Hiroshi Yoshida and Hidetoshi Hayashi and Toshiki Rikiyama and Hyunjung Kim and Youngshik Choe and Kyungjin Kim and Hosun Son and Fuyuhiko Motoi and Shinichi Egawa and Michiaki Unno},
  journal={Anticancer research},
  year={2009},
  volume={29 4},
  pages={
          1201-9
        }
}
Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. The Period2 gene is essential in controlling the circadian rhythm and plays an important role in tumor suppression. We examined whether the overexpression of the mouse Period2 gene (mPer2) in cultured tumor cells from human tissues inhibits cell growth, using the recombinant adenovirus vector AdmPer2. The overexpression of mPer2 in human pancreatic cancer cells (Panc1, Aspc1) reduced… CONTINUE READING
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