Clock gene expression in the retina of melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice.

@article{Dinet2007ClockGE,
  title={Clock gene expression in the retina of melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice.},
  author={Virginie Dinet and Nariman Ansari and Claudia Torres-Farfan and Horst-Werner Korf},
  journal={Journal of pineal research},
  year={2007},
  volume={42 1},
  pages={83-91}
}
In several mammalian species, the retina contains an autonomous circadian clock and is capable of synthesizing melatonin. The function of circadian clocks depends on interlocking transcriptional/translational feedback loops involving several clock genes. Here we investigated the expression of two clock genes (Per1, Cry2) and the level of phosphorylated (p) cyclic AMP response element binding protein (CREB) in retinae of melatonin-deficient (C57BL) with an intact retina and melatonin-proficient… CONTINUE READING