Clock controls circadian period in isolated suprachiasmatic nucleus neurons

@article{Herzog1998ClockCC,
  title={Clock controls circadian period in isolated suprachiasmatic nucleus neurons},
  author={Erik D. Herzog and Joseph S. Takahashi and Gene D. Block},
  journal={Nature Neuroscience},
  year={1998},
  volume={1},
  pages={708-713}
}
The suprachiasmatic nucleus (SCN) is the master circadian pacemaker in mammals, and one molecular regulator of circadian rhythms is the Clock gene. Here we studied the discharge patterns of SCN neurons isolated from Clock mutant mice. Long-term, multielectrode recordings showed that heterozygous Clock mutant neurons have lengthened periods and that homozygous Clock neurons are arrhythmic, paralleling the effects on locomotor activity in the animal. In addition, cells in dispersals expressed a… Expand
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