Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes.

@article{MenaAvila2017ClobenpropitAH,
  title={Clobenpropit, a histamine H3 receptor antagonist/inverse agonist, inhibits [3H]-dopamine uptake by human neuroblastoma SH-SY5Y cells and rat brain synaptosomes.},
  author={Elvia Mena-Avila and Ricardo M{\'a}rquez-G{\'o}mez and Guillermo Aquino-Miranda and Gustavo Nieto-Alamilla and Jos{\'e}-Antonio Arias-Monta{\~n}o},
  journal={Pharmacological reports : PR},
  year={2017},
  volume={70 1},
  pages={
          146-155
        }
}
BACKGROUND Clobenpropit, a potent antagonist/inverse agonist at the histamine H3 receptor (H3R), reduced the cytotoxic action of 6-hydroxydopamine (6-OHDA) in neuroblastoma SH-SY5Y cells transfected with the human H3R. We therefore set out to study whether this effect involved a receptor-independent action on dopamine transport. METHODS The uptake of [3H]-dopamine was assayed in SH-SY5Y cells and rat striatal or cerebro-cortical isolated nerve terminals (synaptosomes). Clobenpropit binding to… CONTINUE READING
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