Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies.

@article{Leon2013ClobazamTD,
  title={Clobazam therapeutic drug monitoring: a comprehensive review of the literature with proposals to improve future studies.},
  author={Jose de Leon and Edoardo Spina and Francisco J D{\'i}az},
  journal={Therapeutic drug monitoring},
  year={2013},
  volume={35 1},
  pages={30-47}
}
BACKGROUND Clobazam was recently approved for Lennox-Gastaut syndrome in the United States. There is no published review article focused on clobazam therapeutic drug monitoring (TDM) in English. METHODS More than 200 clobazam articles identified by a PubMed search were carefully reviewed for information on clobazam pharmacokinetics. Clobazam is mainly metabolized by a cytochrome P450 (CYP) isoenzyme, CYP3A4, to its active metabolite, N-desmethylclobazam. Then, N-desmethylclobazam is mainly… CONTINUE READING

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