Clitocybin A, a novel isoindolinone, from the mushroom Clitocybe aurantiaca, inhibits cell proliferation through G1 phase arrest by regulating the PI3K/Akt cascade in vascular smooth muscle cells.

Abstract

Abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an essential role in the pathogenesis of vascular diseases, such as atherosclerosis, hypertension, and restenosis. Clitocybin A, a novel isoindolinone, isolated from the culture broth of mushroom Clitocybe aurantiaca has been reported to possess free radical scavenging activity. However… (More)

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Cite this paper

@article{Yoo2012ClitocybinAA, title={Clitocybin A, a novel isoindolinone, from the mushroom Clitocybe aurantiaca, inhibits cell proliferation through G1 phase arrest by regulating the PI3K/Akt cascade in vascular smooth muscle cells.}, author={Kyu-Dong Yoo and Eun Seok Park and Yong Lim and Shin-il Kang and Su-Hyang Yoo and Ha-Hee Won and Young-Hee Kim and Ick-dong Yoo and Hwan-Soo Yoo and Jin Tae Hong and Yeo-Pyo Yun}, journal={Journal of pharmacological sciences}, year={2012}, volume={118 2}, pages={171-7} }