Clioquinol targets zinc to lysosomes in human cancer cells.

  title={Clioquinol targets zinc to lysosomes in human cancer cells.},
  author={Haijun Yu and Yunfeng Zhou and Stuart E. Lind and Wei-Qun Ding},
  journal={The Biochemical journal},
  volume={417 1},
We have previously demonstrated that clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) acts as a zinc ionophore and induces apoptosis of human cancer cells; however, the mechanisms of clioquinol/zinc-induced apoptotic cell death remain to be elucidated further. Using fluorescence-labelled probes, the present study has examined intracellular zinc distribution after clioquinol treatment in human cancer cells in order to identify cellular targets for zinc ionophores. DU 145, a human prostate cancer… 

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