Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.

@article{Andersson2009ClioquinolAP,
  title={Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.},
  author={David A Andersson and Clive Gentry and Sian Moss and Stuart Bevan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 20},
  pages={8374-9}
}
The antifungal and amoebicidal drug clioquinol (CQ) was withdrawn from the market when it was linked to an epidemic of subacute myelo-optico-neuropathy (SMON). Clioquinol exerts its anti-parasitic actions by acting as a Cu/Zn chelator and ionophore. Here we show that local injections of CQ produce mechanical hyperalgesia and cold hypersensitivity through a mechanism involving TRPA1 in mice. We also show that CQ activates TRPA1 in a Zn(2+)-dependent manner. Using a different Zn(2+)-ionophore… CONTINUE READING
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