Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-kappaB.

@article{Park2010ClinopodiumGI,
  title={Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-kappaB.},
  author={Seung-Bin Park and Sang-Yong Kim and Kyoungho Suk and Hyun-Shik Lee and Taeg Kyu Kwon and Min-Gyu Ju and Hoon Jae Jeon and Dae-Keun Kim and J Lim and T. Y. Shin},
  journal={Experimental biology and medicine},
  year={2010},
  volume={235 5},
  pages={606-13}
}
Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of the water extract of Clinopodium gracile Matsum var. multicaule (WECG) on the mast cell-mediated allergic inflammation and studied the possible mechanism of action. WECG inhibited compound 48/80-induced systemic anaphylaxis… CONTINUE READING