Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma.

  title={Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma.},
  author={K. J. Jang and Young Soo Song and Si-Hyong Jang and Kyueng-Whan Min and Woong Chae Na and Se Min Jang and Young Jin Jun and Kang Hong Lee and DongHo Choi and Seung Sam Paik},
  volume={56 2},
AIMS Tumour suppressor phosphatase and tensin homologue (PTEN) is an important negative regulator for the PIP3/Akt signalling pathway that promotes cell proliferation and inhibits apoptosis. Inactivation of PTEN by mutation, deletion and promoter hypermethylation has been demonstrated in a range of cancers. The aim was to investigate whether the loss of nuclear PTEN protein expression correlates with conventional clinicopathological parameters and patient survival. METHODS AND RESULTS… CONTINUE READING