Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.

@article{Yang2001ClinicopathologicalSO,
  title={Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.},
  author={Qifeng Yang and Goh Yoshimura and Takaomi Suzuma and Takeshi Tamaki and Teiji Umemura and Motoyuki Nakamura and Yusuke Nakamura and Xinpeng Wang and Ichiro Mori and Takeo Sakurai and Kennichi Kakudo},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 12},
  pages={3869-73}
}
The fragile histidine triad (Fhit) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Loss of Fhit expression is an important step in tumor progression from premalignancy, to in situ, to invasive breast carcinoma. To determine whether the absence of Fhit protein correlates with other established pathological-clinical parameters or prognosis, we assessed Fhit expression using immunohistochemistry in 166 invasive breast… CONTINUE READING
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