Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1α) expression in gastric cancer

  title={Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1α) expression in gastric cancer},
  author={Taro Isobe and Keishiro Aoyagi and Kikuo Koufuji and Kazuo Shirouzu and Akihiro Kawahara and Tomoki Taira and Masayoshi Kage},
  journal={International Journal of Clinical Oncology},
Hypoxia is a common feature of rapidly growing solid tumors. Therefore, cellular adaptation to hypoxia and altered glucose metabolism are fundamental to the biology of cancer cells. Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor for more than 60 genes recognized to control the delivery of oxygen and nutrients through the induction of angiogenesis and glycolysis under hypoxic conditions. Therefore, inhibition of the expression of HIF-1α can be expected to be potentially tumor… CONTINUE READING


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