Clinicopathological implications of TIM3+ tumor-infiltrating lymphocytes and the miR-455-5p/Galectin-9 axis in skull base chordoma patients

@article{Zhou2019ClinicopathologicalIO,
  title={Clinicopathological implications of TIM3+ tumor-infiltrating lymphocytes and the miR-455-5p/Galectin-9 axis in skull base chordoma patients},
  author={Jinpeng Zhou and Yang Jiang and Hongyan Zhang and Lian Zhong Chen and Peng Luo and Long Li and Junshuang Zhao and Fei Lv and Dan Zou and Ye Zhang and Zhitao Jing},
  journal={Cancer Immunology, Immunotherapy},
  year={2019},
  volume={68},
  pages={1157-1169}
}
Chordoma is difficult to eradicate due to high local recurrence rates. The immune microenvironment is closely associated with tumor prognosis; however, its role in skull base chordoma is unknown. The expression of Galectin-9 (Gal9) and tumor-infiltrating lymphocyte (TIL) markers was assessed by immunohistochemistry. Kaplan–Meier and multivariate Cox analyses were used to assessing local recurrence-free survival (LRFS) and overall survival (OS) of patients. MiR-455-5p was identified as a… CONTINUE READING
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