Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions

@article{Yokota2009ClinicopathologicalCO,
  title={Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions},
  author={Osamu Yokota and Kuniaki Tsuchiya and Tetsuaki Arai and Saburo Yagishita and Osamu Matsubara and Akihide Mochizuki and Akira Tamaoka and Mitsuru Kawamura and Hidetoshi Yoshida and Seishi Terada and Hideki Ishizu and Shigetoshi Kuroda and Haruhiko Akiyama},
  journal={Acta Neuropathologica},
  year={2009},
  volume={117},
  pages={429-444}
}
Although frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions (FTLD-TDP) and Pick’s disease are common pathological substrates in sporadic FTLD, clinical differentiation of these diseases is difficult. We performed a retrospective review of medical records and semiquantitative examination of neuronal loss of 20 sporadic FTLD-TDP and 19 Pick’s disease cases. Semantic dementia as the first syndrome developed only in FTLD-TDP patients. Impaired speech output in the early… 
Clinicopathological characteristics of FTLD-TDP showing corticospinal tract degeneration but lacking lower motor neuron loss
Clinical phenotypes in autopsy-confirmed Pick disease
TLDR
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Pick's disease.
TLDR
In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.
TDP-43 pathology in primary lateral sclerosis
TLDR
The extremely minor involvement of LMN, even after very long disease duration in some cases, suggests that PLS is a distinct form of MND in which LMN are spared or protected.
Dopamine Transporter Imaging for Frontotemporal Lobar Degeneration With Motor Neuron Disease
TLDR
Dopamine transporter single photon emission computed tomography revealed abnormal findings in patients with FTLD-MND, which may manifest even before the onset of MND symptoms.
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology
TLDR
FTLD-Tau and FT LD-TDP proteinopathies have distinct severity and regional distribution of WM and GM pathology, which may impact their clinical presentation, with overall greater severity of WM pathology as a distinguishing feature of tauopathies.
Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes
シンポジウム19―4 認知症研究の新しい視点 TDP-43陽性封入体をともなう孤発性FTLDの臨床病理学的特徴
TLDR
It is suggested that the early impairment of semantic memory and asymmetric motor disturbances in sporadic FTLD patients predict FTLD-TDP rather than Pick's disease, while initial behavioral symptoms or non-fluent aphasia without subsequent asymmetricMotor disturbances predict Pick’s disease rather than FTLD -TDP.
Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
TLDR
A pathological continuity between FTLD-TDP and ALS is supported at the level of the LMN system, and lower motor neuron loss and TDP-43-positive skeinlike inclusions were observed in all pathological subtypes.
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