Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions

@article{Yokota2009ClinicopathologicalCO,
  title={Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions},
  author={O. Yokota and K. Tsuchiya and T. Arai and S. Yagishita and O. Matsubara and A. Mochizuki and A. Tamaoka and M. Kawamura and Hidetoshi Yoshida and S. Terada and H. Ishizu and S. Kuroda and H. Akiyama},
  journal={Acta Neuropathologica},
  year={2009},
  volume={117},
  pages={429-444}
}
Although frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions (FTLD-TDP) and Pick’s disease are common pathological substrates in sporadic FTLD, clinical differentiation of these diseases is difficult. We performed a retrospective review of medical records and semiquantitative examination of neuronal loss of 20 sporadic FTLD-TDP and 19 Pick’s disease cases. Semantic dementia as the first syndrome developed only in FTLD-TDP patients. Impaired speech output in the early… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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