Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions
@article{Yokota2009ClinicopathologicalCO, title={Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions}, author={Osamu Yokota and Kuniaki Tsuchiya and Tetsuaki Arai and Saburo Yagishita and Osamu Matsubara and Akihide Mochizuki and Akira Tamaoka and Mitsuru Kawamura and Hidetoshi Yoshida and Seishi Terada and Hideki Ishizu and Shigetoshi Kuroda and Haruhiko Akiyama}, journal={Acta Neuropathologica}, year={2009}, volume={117}, pages={429-444} }
Although frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions (FTLD-TDP) and Pick’s disease are common pathological substrates in sporadic FTLD, clinical differentiation of these diseases is difficult. We performed a retrospective review of medical records and semiquantitative examination of neuronal loss of 20 sporadic FTLD-TDP and 19 Pick’s disease cases. Semantic dementia as the first syndrome developed only in FTLD-TDP patients. Impaired speech output in the early…
66 Citations
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The pathologic course of the disease in FTLD cases with Pick bodies is not uniform and disease duration can be estimated based on early clinical features, having relevance as treatment options, which are likely to be pathology specific, are developed.
Pick's disease.
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- 2012
In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.
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- 2020
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- 2022
Dopamine transporter single photon emission computed tomography revealed abnormal findings in patients with FTLD-MND, which may manifest even before the onset of MND symptoms.
Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology
- Medicine, PsychologyActa neuropathologica communications
- 2021
FTLD-Tau and FT LD-TDP proteinopathies have distinct severity and regional distribution of WM and GM pathology, which may impact their clinical presentation, with overall greater severity of WM pathology as a distinguishing feature of tauopathies.
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- Medicine, BiologyJournal of the Neurological Sciences
- 2010
シンポジウム19―4 認知症研究の新しい視点 TDP-43陽性封入体をともなう孤発性FTLDの臨床病理学的特徴
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- 2010
It is suggested that the early impairment of semantic memory and asymmetric motor disturbances in sporadic FTLD patients predict FTLD-TDP rather than Pick's disease, while initial behavioral symptoms or non-fluent aphasia without subsequent asymmetricMotor disturbances predict Pick’s disease rather than FTLD -TDP.
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- Medicine, BiologyJAMA neurology
- 2014
A pathological continuity between FTLD-TDP and ALS is supported at the level of the LMN system, and lower motor neuron loss and TDP-43-positive skeinlike inclusions were observed in all pathological subtypes.
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