Clinicopathological and tissue indicators of para-aminophenol nephrotoxicity in sprague-dawley rats.

@article{Yang2007ClinicopathologicalAT,
  title={Clinicopathological and tissue indicators of para-aminophenol nephrotoxicity in sprague-dawley rats.},
  author={Amy Z. Yang and Dusko Trajkovic and Oscar Illanes and Fernando Ramiro-Ib{\'a}{\~n}ez},
  journal={Toxicologic pathology},
  year={2007},
  volume={35 4},
  pages={
          521-32
        }
}
A model of para-aminophenol (PAP) nephrotoxicity in Sprague-Dawley rats was utilized to characterize potential indicators of toxicity in the kidney and in biofluids, and to chronicle the progression of acute renal injury. Rats were administered PAP at a low or high dose and examined terminally at 6, 24 and 48 hours (4 animals/group with matching controls). Acute tubular necrosis was observed in the medullary rays (low and high doses) and the outer stripe of outer medulla (high dose only) as… CONTINUE READING