Clinicopathological and prognostic significances of EGFR, KRAS and BRAF mutations in biliary tract carcinomas in Taiwan.

@article{Chang2014ClinicopathologicalAP,
  title={Clinicopathological and prognostic significances of EGFR, KRAS and BRAF mutations in biliary tract carcinomas in Taiwan.},
  author={Yu-ting Chang and M C Chang and Kai-Wen Huang and Chien-Chih Tung and Chiun Yu Hsu and Jau-Min Wong},
  journal={Journal of gastroenterology and hepatology},
  year={2014},
  volume={29 5},
  pages={1119-25}
}
BACKGROUND AND AIM Biliary tract carcinomas (BTCs) are difficult to diagnose and treat. Epidermal growth factor receptor (EGFR) represents a therapeutic target for the BTCs. Mutations of the EGFR gene and the activation of its downstream pathways, including KRAS and BRAF, predict the sensitivity to anti-EGFR treatment. The aims of this study were to analyze… CONTINUE READING