Clinicopathological and biological significance of CDC28 protein kinase regulatory subunit 2 overexpression in human gastric cancer.

@article{Tanaka2011ClinicopathologicalAB,
  title={Clinicopathological and biological significance of CDC28 protein kinase regulatory subunit 2 overexpression in human gastric cancer.},
  author={Fumiaki Tanaka and Shinjiro Wilson Matsuzaki and Koshi Mimori and Yoshiaki Kita and Hiroshi Inoue and Masaki Mori},
  journal={International journal of oncology},
  year={2011},
  volume={39 2},
  pages={
          361-72
        }
}
CDC28 protein kinase regulatory subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have investigated its involvement in gastric cancer. In this study, we focused on the clinical and biological significance of CKS2 over-expression in gastric cancer. The expression of CKS2 mRNA was studied by real-time quantitative reverse transcription polymerase chain reaction, and the expression status in each tumor was examined to… 

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References

SHOWING 1-10 OF 31 REFERENCES
Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer
TLDR
It was shown that CKS2 was significantly upregulated in gastric cancers and a high level of C KS2 was highly correlated with histologic tumor differentiation and pathological grade of the tumor size, lymph node, and metastasis stage.
Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis.
TLDR
Skp2 expression can modulate the malignant phenotype of gastric carcinoma, possibly via p27 proteolysis, and would be a novel target for the treatment of gastrics carcinoma as well as a strong prognostic marker.
Cyclin-dependent kinase 1 gene expression is associated with poor prognosis in gastric carcinoma.
  • Taka-aki Masuda, H. Inoue, +5 authors M. Mori
  • Biology, Medicine
    Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2003
TLDR
Findings indicate that Cks1, as well as Skp2, regulates the expression level of p27 protein in gastric carcinomas and would be a novel target for the treatment of gastrics carcinomas as a strong prognostic marker.
Prognostic significance of cyclin A in gastric cancer
TLDR
The prognostic role of cyclin A in gastric cancer was validated and its correlation with expression of an mRNA stability factor HuR was evaluated, finding one mechanism for its overexpression may depend on cytoplasmic localization of HuR.
Combined Evaluation of Expressions of Cyclin E and p53 Proteins as Prognostic Factors for Patients with Gastric Cancer
TLDR
Combined cyclin E overexpression and p53 expression was significantly associated with poor survival after adjusting for other variables and distinguished a subgroup of patients with poor prognosis.
Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma.
TLDR
The T/N ratio of TIMP-1 mRNA was found to be an independent factor influencing the depth of tumour invasion and was the second most important factor in determining the prognosis of patients.
ckshs expression is linked to cell proliferation in normal and malignant human lymphoid cells
TLDR
Relationships between ckshs expression and cell proliferation are confirmed, and the question of a link with cell differentiation is posed, and relationships with CDKs are analyzed.
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
  • M. Welcker, A. Orian, +4 authors B. Clurman
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
TLDR
It is shown that Fbw7, a component of the SCFFbw 7 ubiquitin ligase and a tumor suppressor, promotes proteasome-dependent c-Myc turnover in vivo and c- myc ubiquitination in vitro.
Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma
TLDR
Elongation factor-1 delta mRNA expression was significantly higher in cancerous compared to noncancerous oesophageal tissues, and a higher expression of EF-1Delta mRNA was correlated with lymph node metastases, advanced disease stages and poorer prognosis for patients with oesophileal carcinoma.
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27
TLDR
It is shown that the missing factor is CDK subunit 1 (Cks1), which belongs to the highly conserved Suc1/Cks family of proteins that bind to some CDKs and phosphorylated proteins and are essential for cell-cycle progression.
...
1
2
3
4
...