Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population

@article{Abubaker2007ClinicopathologicalAO,
  title={Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population},
  author={Jehad Abubaker and Prashant Bavi and Sayer Al-harbi and Mohsen El-Sayed Ibrahim and Abdul Khalid Siraj and Nasser A. Al-Sanea and Alaa Abduljabbar and Luai H. S. Ashari and Samar J Alhomoud and Fouad A Al-Dayel and Shahab Uddin and Khawla S Al-Kuraya},
  journal={Oncogene},
  year={2007},
  volume={27},
  pages={3539-3545}
}
Activation of the phosphatidylinositol 3′-kinase (PI3K)/AKT pathway results in an increase in cell proliferation and survival. Somatic mutations within the PI3K catalytic subunit, PIK3CA are common cause of increasing PI3K activity and are believed to be oncogenic in many cancer types. Few reports addressed the association between PIK3CA mutations and tumor progression specifically in microsatellite instable (MSI) colorectal cancer (CRC). In the present study, we have evaluated PIK3CA… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 50 CITATIONS, ESTIMATED 41% COVERAGE

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

Oncogenic PIK3CA mutations in colorectal cancers and polyps.

  • International journal of cancer
  • 2012
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma

Shi-Yuan Liu, Wei Chen, +5 authors Jin Zhang
  • World journal of gastroenterology
  • 2017

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

The prevalence of PIK3CA mutations in gastric and colon cancer.

  • European journal of cancer
  • 2005
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2007
VIEW 2 EXCERPTS