Clinicopathological Features in Endometrial Carcinoma with Mismatch Repair Deficiency among Chinese Women Younger Than 50 Years of Age

Abstract

Objective: Mismatch repair (MMR) deficiency can lead to genome instability and closely correlated with carcinogenesis of endometrial carcinoma and mainly caused by MMR gene germline mutation known as Lynch syndrome (LS) or epigenetic mechanisms of MLH1 promoter methylation. The main objective of the present study is to correlate the clinicopathological… (More)

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