Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma.

@article{Liu2008ClinicopathologicSO,
  title={Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma.},
  author={Shyun-Yeu Liu and L Chang and Li-Fan Pan and Y T Hung and C Lee and Y L Shieh},
  journal={Oral oncology},
  year={2008},
  volume={44 3},
  pages={277-85}
}
Oral squamous cell carcinoma (SCC) can be vascularized through a process called "tumor cell-lined vessels". Currently, the tumor microenvironment, which is recognized as hypoxic and orchestrated largely by inflammatory cells and defective blood vessels, is considered an important participant in the neoplastic process. We sought to determine their clinicopathologic significance and prognostic implication in oral SCC. Vascular structure was investigated by multistaining with pan-cytokeratin, CD34… CONTINUE READING
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