Clinicopathologic significance of protein induced vitamin K absence or antagonist II and alpha-fetoprotein in hepatocellular carcinoma.

@article{Nakagawa1999ClinicopathologicSO,
  title={Clinicopathologic significance of protein induced vitamin K absence or antagonist II and alpha-fetoprotein in hepatocellular carcinoma.},
  author={Takemasa Nakagawa and Toshihito Seki and Tomohiro Shiro and Motohiro Wakabayashi and Masatoshi Imamura and Tomoo Itoh and Toru Tamai and Akira Nishimura and Noriyo Yamashiki and Koichi Matsuzaki and Noriko Sakaida and Kazuto Inoue and Akiharu Okamura},
  journal={International journal of oncology},
  year={1999},
  volume={14 2},
  pages={281-6}
}
Protein induced vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) have been considered useful serum markers of hepatocellular carcinoma (HCC). In this study, we examined the clinicopathologic significance of these tumour markers in patients with HCCs by measuring their serum levels and performing immunohistochemistry. We studied 349 Japanese patients with HCCs. Their serum PIVKA-II and AFP levels were determined by enzyme immunoassay before treatment. We examined the… CONTINUE READING

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