Clinicopathologic features in colorectal cancer patients with microsatellite instability.

  title={Clinicopathologic features in colorectal cancer patients with microsatellite instability.},
  author={Chandrajit P Raut and Timothy M Pawlik and Miguel Rodriguez-Bigas},
  journal={Mutation research},
  volume={568 2},
The microsatellite instability (MSI) mutational pathway is critical to carcinogenesis in a small but significant proportion of colorectal cancers. While MSI is identified in most cancers in individuals with hereditary non-polyposis colorectal cancer, the majority of MSI tumors are found in individuals with sporadic disease. Colorectal cancers arising as a result of MSI have distinct clinicopathologic features distinguishing them from those with microsatellite stability. MSI colorectal cancers… CONTINUE READING


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