Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1α in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study.

@article{Wang2011ClinicopathologicCO,
  title={Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1α in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study.},
  author={Zhen Wang and Qin Shi and Zemin Wang and Yongping Gu and Yueping Shen and Maoming Sun and Min Deng and Hua Zhang and Junchu Fang and Shuying Zhang and Fang Xie},
  journal={Pathology, research and practice},
  year={2011},
  volume={207 8},
  pages={505-13}
}
CD24(-/low)CD44(+) cells have been identified as putative cancer stem cells (CSCs) in breast cancer. However, the expression of these markers, as well as their association with clinical parameters or tumor microenvironment of breast cancer, remains largely unknown. In the present study, we examined the expression of CD44, CD24, VEGF, and HIF-1α in human breast tumor tissues and assessed their clinicopathological correlations. We investigated tissue samples, including 117 cases of invasive… CONTINUE READING
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