Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer.

@article{Morris2014ClinicopathologicCA,
  title={Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer.},
  author={Van Karlyle Morris and F. Anthony San Lucas and Michael J Overman and Cathy Eng and Mar{\'i}a P Morelli and Z Jiang and Raja Luthra and Funda Meric-Bernstam and Dipen M. Maru and Paul Scheet and Scott Kopetz and Eduardo VilarE. Vilar},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2014},
  volume={25 10},
  pages={2008-14}
}
BACKGROUND KRAS mutations in codons 12 and 13 are present in ∼40% of all colorectal cancers (CRC). Activating mutations in codons 61 and 146 of KRAS and in codons 12, 13, and 61 of NRAS also occur but are less frequent. The clinicopathologic features and gene expression profiles of this latter subpopulation of RAS-mutant colorectal tumors have not yet been clearly defined but in general are treated similarly to those with KRAS 12 or 13 mutations. PATIENTS AND METHODS Records of patients with… CONTINUE READING
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