Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women.

  title={Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women.},
  author={Naomi Maruyama and Yasuo Miyoshi and Tetsuya Taguchi and Yasuhiro Tamaki and Morito Monden and Shinzaburo Noguchi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 2 Pt 1},
PURPOSE Somatic mutations of PIK3CA, which encodes the p110alpha catalytic subunit of phosphatidylinositol 3-kinase, have recently been shown to play an important role in the pathogenesis and progression of human breast cancers. In this study, the frequency of PIK3CA mutations and their relationship with clinicopathologic and biological variables were investigated in Japanese breast cancers. EXPERIMENTAL DESIGN Mutational analysis of PIK3CA was done in 188 primary breast cancers of Japanese… CONTINUE READING


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