Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis.

@article{Lima2004ClinicobiologicalIA,
  title={Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56-/+dim chronic natural killer cell large granular lymphocytosis.},
  author={Margarida Lima and Julia Almeida and Andr{\'e}s Garc{\'i}a Montero and Maria dos Anjos Teixeira and Maria Lu{\'i}s Queir{\'o}s and Ana Helena Santos and Ana Balanzategui and Alexandra Estevinho and Mar{\'i}a del Carmen Alguero and Paloma B{\'a}rcena and Sonia Maria Fonseca and Maria Lu{\'i}s Amorim and Jos{\'e} Manuel Cabeda and Luciana Pinho and Marcos Gonzalez and Jes{\'u}s San Miguel and Benvindo Justiça and Alberto Orfao},
  journal={The American journal of pathology},
  year={2004},
  volume={165 4},
  pages={1117-27}
}
Indolent natural killer (NK) cell lymphoproliferative disorders include a heterogeneous group of patients in whom persistent expansions of mature, typically CD56(+), NK cells in the absence of any clonal marker are present in the peripheral blood. In the present study we report on the clinical, hematological, immunophenotypic, serological, and molecular features of a series of 26 patients with chronic large granular NK cell lymphocytosis, whose NK cells were either CD56(-) or expressed very low… CONTINUE READING
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