Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis

@article{Tallantyre2010ClinicopathologicalET,
  title={Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis},
  author={Emma Clare Tallantyre and Lars B{\o} and O Al-Rawashdeh and Trudy Owens and Chris H. Polman and James S Lowe and Nikos Evangelou},
  journal={Multiple Sclerosis},
  year={2010},
  volume={16},
  pages={406 - 411}
}
Growing evidence suggests that axonal degeneration rather than demyelination is the pathological substrate underlying chronic, irreversible disability in multiple sclerosis. However, direct evidence linking clinical disability measured in vivo with corresponding post-mortem measures of axonal pathology is lacking. Our objective in this study was to investigate the relationship between motor disability accumulated by patients with multiple sclerosis during life and the degree of axonal loss… 

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