Clinically significant pharmacokinetic drug interactions with benzodiazepines

  title={Clinically significant pharmacokinetic drug interactions with benzodiazepines},
  author={Einosuke Tanaka},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  • E. Tanaka
  • Published 1 October 1999
  • Psychology, Medicine, Chemistry, Biology
  • Journal of Clinical Pharmacy and Therapeutics
The reports of interactions between benzodiazepines (BZPs) and other drugs (e.g. antidepressants, selective serotonin reuptake inhibitors, antiulcer drugs, antiepileptic drugs, macrolide antibiotics) during their combined use are reviewed. In general, metabolism of BZPs is delayed when combined with a number of other drugs but some reports have suggested otherwise. 

Clinically significant pharmacokinetic drug interactions with psychoactive drugs: antidepressants and antipsychotics and the cytochrome P450 system

It is useful to phenotype CYP1C19 and CYP2D6 (extensive metabolizers or poor metabolizers) before giving psychotherapeutic drugs whose metabolism might be inhibited by other drugs.

Benzodiazepines in epilepsy: pharmacology and pharmacokinetics

Among these BZDs, clorazepate has a unique profile that includes a long half‐life of its active metabolite and slow onset of tolerance, which could theoretically help minimize adverse events.

A Review of the Metabolism and Potential Drug-drug Interactions With Addictive Drugs

A list of potential DDIs between prescription drugs and addictive drugs is compiled to create a list allowing prescribers to make more informed decisions when prescribing a medication to PWUD.

Herbal Pharmacokinetics : A Practitioner Update With Reference to St . John ' s Wort ( Hypericum perforatum ) Herb-Drug Interactions

Factors affecting inter-individual variability of CYP450 expression are discussed, as well as the role of these mechanisms in pharmacokinetic interactions, and guidelines for practitioners on St. John's Wort usage are suggested.

Herbal Pharmacokinetics : A Practitioner Update With Reference to St . John ’ s Wort ( Hypericum perforatum )

Why Pharmacokinetics? Herbalists have long studied the effect of herbal medicines on the body, but have hitherto paid less attention to the effects of the body on herbal medicines. This dichotomy

Clinically Significant Psychotropic Drug-Drug Interactions in the Primary Care Setting

Increased awareness of clinically relevant psychotropic drug interactions can aid clinicians to achieve optimal therapeutic outcomes in patients in the primary care setting.

Concomitant use of policosanol and benzodiazepines in older patients

Policosanol is a cholesterol-lowering drug well tolerated in different populations, including those with high consumption of concomitant drugs, and the frequency of adverse events (AE) has been very low, suggesting a low risk of adverse drug interactions.

Clinically important drug–drug interactions in primary care

An investigation of potentially serious DDIs, using a university primary care–based system capturing prescription records from its primary care services, is reported on.

Lack of Pharmacokinetic Interactions Between Steady-State Zonisamide and Valproic Acid in Patients with Epilepsy

There is no apparent clinically significant effect of steady-state dosing of zonisamide on valproic acid pharmacokinetics, and valprooic acid did not appear to affect the pharmacokinetic ofZonisamide, indicating that no dosage adjustment of either drug should be required when they are used in combination in patients with epilepsy.

Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance

A number of therapeutic drugs with different structures and mechanisms of action have been reported to undergo metabolic activation by Phase I or Phase II drug-metabolizing enzymes. The bioactivation



Pharmacokinetic interactions between acute alcohol ingestion and single doses of benzodiazepines, and tricyclic and tetracyclic antidepressants – an update

Recent reports of interactions between alcohol and benzodiazepines, tricyclic and tetracyclic antidepressants during their acute concomitant use are reviewed. Acute ingestion of alcohol (ethanol)

[Drug interactions of midazolam].

In vitro screening factors that could interfere with the rate of midazolam biotransformation (drug-drug interactions) were investigated andabolite production (1'-and 4-OH-midazol am) was monitored in human liver microsomes.

Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system.

The article focuses on the effects of the serotonin selective reuptake inhibitors (SSRIs) on specific drug metabolizing isoenzymes: CYP2D6, CYP3A3/4, CYP1A2, CYP2C9, and CYP2C19. Both in vitro and in

Pharmacokinetic Drug Interactions with Anti-Ulcer Drugs

  • R. Negro
  • Medicine, Biology
    Clinical pharmacokinetics
  • 1998
This article reviews pharmacokinetic interactions with anti-ulcer drugs, paying particular attention to those which have clinically relevant adverse effects.

Drug interactions with azithromycin and the macrolides: an overview.

  • M. Nahata
  • Medicine, Biology
    The Journal of antimicrobial chemotherapy
  • 1996
There is no evidence that azithromycin, unlike most other macrolides, interacts with any of these agents to produce clinically significant adverse effects, and the explanation for this variation appears to be azathromycin's inability to induce and bind to the cytochrome P450 IIIA enzyme system.

Drug Interactions with Proton Pump Inhibitors

A synergy has been confirmed between omeprazole and amoxicillin or clarithromycin in the antibacterial effect against Helicobacter pylori and the small proportion of slow metabolisers is at no additional risk for clinically important drug interactions.

Clinically important pharmacokinetic drug–drug interactions: role of cytochrome P450 enzymes

  • E. Tanaka
  • Biology, Medicine
    Journal of clinical pharmacy and therapeutics
  • 1998
Understanding the mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple‐drug therapies and in the future, it may help to identify individuals at greatest risk of drug interactions and adverse events.

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

Ketoconazole and itraconazole may seriously interact with some of the substrates of CYP3A4 (e.g., terfenadine) and their possible interaction with triazolam in humans is important to uncover.

The emerging role of cytochrome P450 3A in psychopharmacology.

Knowing the substrates, inhibitors, and inducers of CYP3A3/ and other cytochrome P450 isoforms may help clinicians to anticipate and avoid pharmacokinetic drug interactions and improve rational prescribing practices.

Benzodiazepines and Ethanol: Assessment of the Effects and Consequences of Psychotropic Drug Interactions

It is suggested that the ethanol-benzodiazepine interaction is probably less important than those involving ethanol and other psychotropic drugs, such as cannabinoids, neuroleptics, stimulants, and antidepressants.