Clinically significant pharmacokinetic drug interactions with benzodiazepines

@article{Tanaka1999ClinicallySP,
  title={Clinically significant pharmacokinetic drug interactions with benzodiazepines},
  author={Einosuke Tanaka},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  year={1999},
  volume={24}
}
  • E. Tanaka
  • Published 1 October 1999
  • Psychology, Medicine, Chemistry, Biology
  • Journal of Clinical Pharmacy and Therapeutics
The reports of interactions between benzodiazepines (BZPs) and other drugs (e.g. antidepressants, selective serotonin reuptake inhibitors, antiulcer drugs, antiepileptic drugs, macrolide antibiotics) during their combined use are reviewed. In general, metabolism of BZPs is delayed when combined with a number of other drugs but some reports have suggested otherwise. 

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References

SHOWING 1-10 OF 117 REFERENCES

Pharmacokinetic interactions between acute alcohol ingestion and single doses of benzodiazepines, and tricyclic and tetracyclic antidepressants – an update

Recent reports of interactions between alcohol and benzodiazepines, tricyclic and tetracyclic antidepressants during their acute concomitant use are reviewed. Acute ingestion of alcohol (ethanol)

Selective Serotonin Reuptake Inhibitors and CNS Drug Interactions

In vitro and in vivo evidence for drug interactions between SSRIs and other central nervous system drugs is reviewed, with special emphasis on antipsychotics, tricyclic anti-depressants and benzodiazepines.

[Drug interactions of midazolam].

In vitro screening factors that could interfere with the rate of midazolam biotransformation (drug-drug interactions) were investigated andabolite production (1'-and 4-OH-midazol am) was monitored in human liver microsomes.

Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system.

The article focuses on the effects of the serotonin selective reuptake inhibitors (SSRIs) on specific drug metabolizing isoenzymes: CYP2D6, CYP3A3/4, CYP1A2, CYP2C9, and CYP2C19. Both in vitro and in

Pharmacokinetic Drug Interactions with Anti-Ulcer Drugs

  • R. Negro
  • Medicine, Biology
    Clinical pharmacokinetics
  • 1998
This article reviews pharmacokinetic interactions with anti-ulcer drugs, paying particular attention to those which have clinically relevant adverse effects.

Drug interactions with azithromycin and the macrolides: an overview.

  • M. Nahata
  • Medicine, Biology
    The Journal of antimicrobial chemotherapy
  • 1996
There is no evidence that azithromycin, unlike most other macrolides, interacts with any of these agents to produce clinically significant adverse effects, and the explanation for this variation appears to be azathromycin's inability to induce and bind to the cytochrome P450 IIIA enzyme system.

Drug Interactions with Proton Pump Inhibitors

A synergy has been confirmed between omeprazole and amoxicillin or clarithromycin in the antibacterial effect against Helicobacter pylori and the small proportion of slow metabolisers is at no additional risk for clinically important drug interactions.

Update: Clinically Significant Cytochrome P‐450 Drug Interactions

Of the more than 30 human isoenzymes identified to date, the major ones responsible for drug metabolism include CYP3A4, CYP1A2, and the CYP2C subfamily.

Oral triazolam is potentially hazardous to patients receiving systemic antimycotics ketoconazole or itraconazole

Ketoconazole and itraconazole may seriously interact with some of the substrates of CYP3A4 (e.g., terfenadine) and their possible interaction with triazolam in humans is important to uncover.

Alcohol interactions with benzodiazepines and cocaine.

  • A. Hoyumpa
  • Medicine
    Advances in alcohol & substance abuse
  • 1984
Chronic alcohol exposure causes induction of hepatic microsomal enzyme activity and enhances the production of metabolites that prove injurious to the liver, thereby augmenting the hepatotoxic effect of alcohol.
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