Clinically significant pharmacokinetic drug interactions between antiepileptic drugs.

  title={Clinically significant pharmacokinetic drug interactions between antiepileptic drugs.},
  author={Einosuke Tanaka},
  journal={Journal of clinical pharmacy and therapeutics},
  volume={24 2},
  • Einosuke Tanaka
  • Published 1999 in Journal of clinical pharmacy and therapeutics
Pharmacokinetic interactions between antiepileptics represent a major potential complication of epilepsy treatment because drug combinations are common. This review discusses pharmacokinetic drug interactions of clinical significance involving antiepileptics and cytochrome P450 (CYP). Most commonly used antiepileptics are eliminated through hepatic metabolism, catalysed by the enzymes CYP2C9, CYP2C19 and CYP3A4 and uridine diphosphate glucuronosyltransferase (UDGPT). Antiepileptics are… CONTINUE READING

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