Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays.

@article{Kuwahara2009ClinicallyRR,
  title={Clinically relevant radioresistant cells efficiently repair DNA double-strand breaks induced by X-rays.},
  author={Yoshikazu Kuwahara and Li Li and Taisuke Baba and Hironobu Nakagawa and Tsutomu Shimura and Yoichiro Yamamoto and Yasuhito Ohkubo and Manabu Fukumoto},
  journal={Cancer science},
  year={2009},
  volume={100 4},
  pages={747-52}
}
Radiotherapy is one of the major therapeutic modalities for eradicating malignant tumors. However, the existence of radioresistant cells remains one of the most critical obstacles in radiotherapy and radiochemotherapy. Standard radiotherapy for tumor treatment consists of approximately 2 Gy once a day, 5 days a week, over a period of 5-8 weeks. To understand the characteristics of radioresistant cells and to develop more effective radiotherapy, we established a novel radioresistant cell line… CONTINUE READING