Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms.

@article{Manzardo2015ClinicallyRG,
  title={Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms.},
  author={Ann M. Manzardo and Austen McGuire and Merlin G. Butler},
  journal={Gene},
  year={2015},
  volume={560 2},
  pages={
          184-94
        }
}
OBJECTIVE Alcoholism arises from combined effects of multiple biological factors including genetic and non-genetic causes with gene/environmental interaction. Intensive research and advanced genetic technology has generated a long list of genes and biomarkers involved in alcoholism neuropathology. These markers reflect complex overlapping and competing effects of possibly hundreds of genes which impact brain structure, function, biochemical alcohol processing, sensitivity and risk for… 
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References

SHOWING 1-10 OF 107 REFERENCES
REVIEW: The genetics of alcoholism: identifying specific genes through family studies
Alcoholism is a complex disorder with both genetic and environmental risk factors. Studies in humans have begun to elucidate the genetic underpinnings of the risk for alcoholism. Here we briefly
Genome-wide association study of alcohol dependence implicates a region on chromosome 11.
TLDR
Combining evidence from the case-control study, the follow-up in families, and gene expression provided strongest support for the association of a cluster of genes on chromosome 11 with alcohol dependence.
Human variation in alcohol response is influenced by variation in neuronal signaling genes.
TLDR
The conclusion that neuronal signaling is mechanistically involved in alcohol's cellular and behavioral effects is supported and neuronal signaling, particularly glutamate signaling, is a prime target for translational studies to understand and eventually modulate alcohol's effects.
Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol Dependence.
TLDR
Using quantitative measures of components of alcohol dependence, several regions of the genome that may contain susceptibility loci for specific alcohol-related traits are identified and merit additional study.
Genetic Influences on the Development of Alcoholism
  • M. Enoch
  • Biology, Medicine
    Current Psychiatry Reports
  • 2013
TLDR
The strongest findings are with genes encoding alcohol metabolizing enzymes, and it has become apparent that variants in stress-related genes such as CRHR1, may only confer risk in individuals exposed to trauma, particularly in early life.
Using genetic information from candidate gene and genome‐wide association studies in risk prediction for alcohol dependence
TLDR
It is suggested that SNPs currently have limited clinical utility, but there is potential for enhanced predictive ability with better understanding of the large number of variants that might contribute to risk.
Genome-wide search for genes affecting the risk for alcohol dependence.
TLDR
There was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.
Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals
TLDR
A consistent re-programming of gene expression in alcohol abusers that reliably discriminates alcoholic from non-alcoholic individuals is revealed.
Genomic screen for loci associated with alcohol dependence in Mission Indians
TLDR
Results corroborate the importance of several chromosomal regions highlighted in prior segregation studies in alcoholism and further identify new regions of the genome that may be unique to either the restricted phenotypes evaluated or this population of Mission Indians.
A Quantitative-Trait Genome-Wide Association Study of Alcoholism Risk in the Community: Findings and Implications
TLDR
Meta-analyses of consumption data may contribute usefully to gene discovery, and through accumulation across studies, GWAS data may become valuable for improved genetic risk differentiation in research in biological psychiatry (e.g., prospective high-risk or resilience studies).
...
1
2
3
4
5
...