Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.

@article{McPherson2012ClinicallyRG,
  title={Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.},
  author={Craig J. McPherson and Lisa M Aschenbrenner and Brian M Lacey and Kelly C. Fahnoe and Margaret M Lemmon and Steven M Finegan and Baswanth Tadakamalla and John P O'donnell and John P. Mueller and Andrew P. Tomaras},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 12},
  pages={6334-42}
}
The incidence of hospital-acquired infections with multidrug-resistant (MDR) Gram-negative pathogens is increasing at an alarming rate. Equally alarming is the overall lack of efficacious therapeutic options for clinicians, which is due primarily to the acquisition and development of various antibiotic resistance mechanisms that render these drugs ineffective. Among these mechanisms is the reduced permeability of the outer membrane, which prevents many marketed antibiotics from traversing this… CONTINUE READING
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New definitions of extended-spectrum TABLE 6 In vivo resistance to MC-1 requires inactivation of two distinct outer membrane siderophore receptors Strain PD50 (mg/kg/dose) 95% CI PAO1

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