Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis

@article{Miller2005ClinicallyIS,
  title={Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis},
  author={D. Miller and F. Barkhof and X. Montalban and A. Thompson and M. Filippi},
  journal={The Lancet Neurology},
  year={2005},
  volume={4},
  pages={281-288}
}
  • D. Miller, F. Barkhof, +2 authors M. Filippi
  • Published 2005
  • Medicine
  • The Lancet Neurology
  • In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the prognosis for patients who present with a CIS have been sought, because only 30-70% of patients with a CIS develop MS. When clinically silent brain lesions are seen on MRI, the likelihood of developing MS is high. MS can be diagnosed within 3 months of CIS presentation with certain MRI and CSF criteria. Disability… CONTINUE READING
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