Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis

@article{Miller2005ClinicallyIS,
  title={Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis},
  author={David J. Miller and Frederik Barkhof and Xavier Montalban and Alan J. Thompson and Massimo Filippi},
  journal={The Lancet Neurology},
  year={2005},
  volume={4},
  pages={281-288}
}
In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the prognosis for patients who present with a CIS have been sought, because only 30-70% of patients with a CIS develop MS. When clinically silent brain lesions are seen on MRI, the likelihood of developing MS is high. MS can be diagnosed within 3 months of CIS presentation with certain MRI and CSF criteria. Disability… 
Clinically Isolated Syndromes : Clinical Characteristics , Differential Diagnosis , and Management Klinik
Clinically isolated syndrome (CIS) is a term that describes the first clinical onset of potential multiple sclerosis (MS). The term CIS is typically applied to young adults with episodes of acute or
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A single-center prospective longitudinal study aimed at identification of the most powerful independent predictors for conversion from CIS to MS, utilizing the 2010 McDonald MS criteria and focusing on selected demographic, clinical, radiographical, cerebrospinal fluid, OCB and electrophysiological parameters.
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Japanese CIS patients seemed to show less brain lesions than those in western countries, suggesting low disease activity of Japanese MS patients.
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