Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization.

@article{Weber1996ClinicallyDS,
  title={Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization.},
  author={Ruthild G. Weber and Clemens Sommer and Friedrich K. Albert and Marika Kiessling and Thomas Cremer},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1996},
  volume={74 1},
  pages={108-19}
}
Studies investigating genetic alterations potentially constituting prognostic factors in glioblastoma multiforme (GBM) have centered mainly around amplification events. Comparative genomic hybridization (CGH) is a recent molecular cytogenetic technique that allows the detection of chromosomal imbalances and amplification sites in tumor DNA prepared from fresh or archival material. A group of 94 patients with GBM underwent surgery followed by a standard course of radiotherapy. Neuroradiologic… CONTINUE READING