Clinically Translatable Cell Tracking and Quantification by MRI in Cartilage Repair Using Superparamagnetic Iron Oxides

@inproceedings{Buul2011ClinicallyTC,
  title={Clinically Translatable Cell Tracking and Quantification by MRI in Cartilage Repair Using Superparamagnetic Iron Oxides},
  author={Gerben M. van Buul and Gyula Kotek and Piotr Wielopolski and Eric Farrell and Pieter Koen Bos and Harrie Weinans and Anja U. Grohnert and Holger Jahr and Jan A. N. Verhaar and Gabriel P. Krestin and Gerjo J. V. M. van Osch and Monique Bernsen},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Articular cartilage has very limited intrinsic regenerative capacity, making cell-based therapy a tempting approach for cartilage repair. Cell tracking can be a major step towards unraveling and improving the repair process of these therapies. We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived mesenchymal stem cells (hBMSCs) regarding effectivity, cell viability, long term metabolic cell activity, chondrogenic differentiation and hBMSC secretion… CONTINUE READING