Clinically Significant Grapefruit Juice-Drug Interactions

@article{Mccloskey2008ClinicallySG,
  title={Clinically Significant Grapefruit Juice-Drug Interactions},
  author={W. Mccloskey and Kathy Zaiken and R. Couris},
  journal={Nutrition Today},
  year={2008},
  volume={43},
  pages={19-26}
}
T he ability of grapefruit juice to increase drug levels in blood was accidentally discovered during a pharmacokinetic study designed to evaluate an interaction between felodipine (Plendil), a drug prescribed for treatment of hypertension, and ethanol. Double-strength grapefruit juice was used to mask the taste of the ethanol in this randomized, crossover, double-blind study. A nonintoxicating dose of ethanol or placebo was administered to subjects, followed by a 5-mg dose of felodipine. For… Expand
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