Clinically Relevant Doses of Enalapril Mitigate Multiple Organ Radiation Injury.

@article{Cohen2016ClinicallyRD,
  title={Clinically Relevant Doses of Enalapril Mitigate Multiple Organ Radiation Injury.},
  author={Eric P. Cohen and Brian L. Fish and John E Moulder},
  journal={Radiation research},
  year={2016},
  volume={185 3},
  pages={
          313-8
        }
}
Angiotensin-converting enzyme inhibitors (ACEi) are effective mitigators of radiation nephropathy. To date, their experimental use has been in fixed-dose regimens. In clinical use, doses of ACEi and other medication may be escalated to achieve greater benefit. We therefore used a rodent model to test the ACEi enalapril as a mitigator of radiation injury in an escalating-dose regimen. Single-fraction partial-body irradiation (PBI) with one hind limb out of the radiation field was used to model… CONTINUE READING

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