• DOI:10.2165/00003088-199630060-00002
Corpus ID: 22389544

Clinically Important Drug Interactions with Anticoagulants

@article{Harder1996ClinicallyID,
  title={Clinically Important Drug Interactions with Anticoagulants},
  author={S. Harder and P. Th{\"u}rmann},
  journal={Clinical Pharmacokinetics},
  year={1996},
  volume={30},
  pages={416-444}
}

S. Harder, P. Thürmann

Published 1996

Medicine

Clinical Pharmacokinetics

SummaryCoumarin derivatives combine 3 unfavourable properties which make them prone to potentially life threatening drug-drug interactions: (i) high protein binding; (ii) cytochrome P450 dependent metabolism; and (iii) a narrow therapeutic range.An entire list of drugs which are supposed to interact with coumarins (mostly with warfarin) comprises about 250 different compounds. Noteworthy are the interactions with cardiovascular or antilipidaemic drugs which are often coadministered with… CONTINUE READING

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