Clinically Approved Drugs against CNS Diseases as Potential Therapeutic Agents To Target Brain-Eating Amoebae.

@article{Anwar2019ClinicallyAD,
  title={Clinically Approved Drugs against CNS Diseases as Potential Therapeutic Agents To Target Brain-Eating Amoebae.},
  author={Ayaz Anwar and Kavitha Rajendran and Ruqaiyyah Siddiqui and Muhammad Raza Shah and Naveed Ahmed Khan},
  journal={ACS chemical neuroscience},
  year={2019},
  volume={10 1},
  pages={
          658-666
        }
}
Central nervous system (CNS) infections caused by free-living amoebae such as Acanthamoeba species and Naegleria fowleri are rare but fatal. A major challenge in the treatment against the infections caused by these amoebae is the discovery of novel compounds that can effectively cross the blood-brain barrier to penetrate the CNS. It is logical to test clinically approved drugs against CNS diseases for their potential antiamoebic effects since they are known for effective blood-brain barrier… 
Repurposing of drugs is a viable approach to develop therapeutic strategies against central nervous system-related pathogenic amoebae.
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Some of the success stories of drugs repositioned against neglected parasitic diseases are highlighted and future potential for effective and sustainable drug development against brain-eating amoebae infections is identified.
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Acanthamoeba in Southeast Asia – Overview and Challenges
TLDR
This review attempts to provide an overview of the available data and studies on the occurrence of pathogenic Acanthamoeba among the Association of Southeast Asian Nations (ASEAN) members with the aim of identifying some potential contributing factors such as distribution, demographic profile of the patients, possible source of the parasite, mode of transmission and treatment.
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