Clinical value of tapentadol extended-release in painful diabetic peripheral neuropathy.


Painful diabetic peripheral neuropathy is difficult to treat, partially because the underlying mechanism of pain is not fully understood. Various treatment guidelines recommend first-line agents, such as α2-δ ligands, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants but combination therapy of alternative agents including opiates… (More)
DOI: 10.1586/17512433.2014.889562