Clinical utility of thiopurine S-methyltransferase genotyping.

  title={Clinical utility of thiopurine S-methyltransferase genotyping.},
  author={H{\`e}ctor Corominas and Montserrat Baiget},
  journal={American journal of pharmacogenomics : genomics-related research in drug development and clinical practice},
  volume={4 1},
Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that plays a major role in the metabolism of thiopurine drugs such as mercaptopurine and azathioprine. The interindividual differences in response to thiopurine administration is in part due to the presence of genetic polymorphisms in the gene that regulates TPMT activity. TPMT genotype correlates well with the in vivo enzyme activity within erythrocytes. Patients with genetically determined decreased TPMT activity develop severe… CONTINUE READING