Clinical utility of plasma Epstein-Barr virus DNA and ERCC1 single nucleotide polymorphism in nasopharyngeal carcinoma.

@article{Hui2015ClinicalUO,
  title={Clinical utility of plasma Epstein-Barr virus DNA and ERCC1 single nucleotide polymorphism in nasopharyngeal carcinoma.},
  author={Edwin Pun Hui and B B Ma and K. C. Allen Chan and Charles Ming Lok Chan and Cesar Wong and Ka Fai To and Anthony W. H. Chan and Stewart Yuk Tung and Wai Tong Ng and Ashley Chi Kin Cheng and Victor Ho-Fun Lee and Stephen L. Chan and Herbert H F Loong and M K M Kam and Sing-fai Leung and Rosalie N L Ho and Frankie Mo and Roger Kai-cheong Ngan and Anthony Tak Cheung Chan},
  journal={Cancer},
  year={2015},
  volume={121 16},
  pages={2720-9}
}
BACKGROUND Single nucleotide polymorphism (SNP) of the excision repair cross-complementing group 1 (ERCC1) gene has been linked with sensitivity to platinum and radiation. The authors hypothesized that the ERCC1 genotype for the SNPs cytosine-to-thymine substitution at codon 118 (C118T) and cytosine-to-adenine substitution at codon 8092 (C8092A) is prognostic in patients with nasopharyngeal carcinoma (NPC) who receive either radiotherapy (RT) or cisplatin plus RT. METHODS The authors tested… CONTINUE READING
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