Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features.

@article{Fuller2003ClinicalUO,
  title={Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features.},
  author={Christine e. Fuller and Robert E. Schmidt and Kevin A. Roth and Peter C. Burger and Bernd Walter Scheithauer and Ruma Banerjee and Kathryn Trinkaus and Richard A. Lytle and Arie Perry},
  journal={Journal of neuropathology and experimental neurology},
  year={2003},
  volume={62 11},
  pages={1118-28}
}
Gliomas with hybrid oligodendroglial/astrocytic features are diagnostically problematic, and our ability to predict tumor behavior is limited. Some likely represent intermingled mixed oligoastrocytomas (MOAs), though precise diagnostic criteria and specific markers for this lesion are lacking. From the files at Washington University (1987-2000), 155 "ambiguous" glioma/intermingled MOA candidates were independently classified and graded by 5 neuropathologists, with consensus-derived pure… CONTINUE READING