Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies.

@article{Edelmann2009ClinicalUO,
  title={Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies.},
  author={Lisa J. Edelmann and Kurt Hirschhorn},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1151},
  pages={157-66}
}
Microarray-based comparative genomic hybridization (array CGH) has revolutionized clinical cytogenetics, as it provides a relatively quick method to scan the genome for gains and losses of chromosomal material with significantly higher resolution and greater clinical yield than was previously possible. A number of different array CGH platforms have emerged and are being used successfully in the diagnostic setting. In the past few years, these new methodologies have led to the identification of… CONTINUE READING

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Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies .
Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies .
Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies .
Microarray - based comparative genomic hybridization ( array CGH ) has revolutionized clinical cytogenetics , as it provides a relatively quick method to scan the genome for gains and losses of chromosomal material with significantly higher resolution and greater clinical yield than was previously possible .
In the past few years , these new methodologies have led to the identification of novel genomic disorders in patients with developmental delay / mental retardation and/or multiple congenital anomalies ( DD / MR / MCA ) as well as the discovery that each individual carries inherited copy number variations ( CNV ) whose contributions to genetic variation and complex disease are not yet well understood .
Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies .
In the past few years , these new methodologies have led to the identification of novel genomic disorders in patients with developmental delay / mental retardation and/or multiple congenital anomalies ( DD / MR / MCA ) as well as the discovery that each individual carries inherited copy number variations ( CNV ) whose contributions to genetic variation and complex disease are not yet well understood .
In the past few years , these new methodologies have led to the identification of novel genomic disorders in patients with developmental delay / mental retardation and/or multiple congenital anomalies ( DD / MR / MCA ) as well as the discovery that each individual carries inherited copy number variations ( CNV ) whose contributions to genetic variation and complex disease are not yet well understood .
In the past few years , these new methodologies have led to the identification of novel genomic disorders in patients with developmental delay / mental retardation and/or multiple congenital anomalies ( DD / MR / MCA ) as well as the discovery that each individual carries inherited copy number variations ( CNV ) whose contributions to genetic variation and complex disease are not yet well understood .
In the past few years , these new methodologies have led to the identification of novel genomic disorders in patients with developmental delay / mental retardation and/or multiple congenital anomalies ( DD / MR / MCA ) as well as the discovery that each individual carries inherited copy number variations ( CNV ) whose contributions to genetic variation and complex disease are not yet well understood .
Microarray - based comparative genomic hybridization ( array CGH ) has revolutionized clinical cytogenetics , as it provides a relatively quick method to scan the genome for gains and losses of chromosomal material with significantly higher resolution and greater clinical yield than was previously possible .
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