Clinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancer.


Mutation of the p53 gene is a key event in the carcinogenesis of many different types of tumours. These can occur throughout the length of the p53 gene. Anti-p53 auto-antibodies are commonly produced in response to these p53 mutations. This review firstly describes the various mechanisms of p53 dysfunction and their association with subsequent… (More)
DOI: 10.3748/wjg.v19.i29.4651