Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation

@inproceedings{Bae2016ClinicalUO,
  title={Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation},
  author={Ja Seong Bae and Yourha Kim and Sora Jeon and Se Hee Kim and Tae Jung Kim and Sohee Lee and Min-Hee Kim and Dong Jun Lim and Youn Soo Lee and Chan Kwon Jung},
  booktitle={Diagnostic pathology},
  year={2016}
}
BACKGROUND Mutations in the TERT promoter, ALK rearrangement, and the BRAF V600E mutation are associated with aggressive clinicopathologic features in thyroid cancers. However, little is known about the impact of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of BRAF mutations. METHODS We performed Sanger sequencing to detect BRAF V600E and TERT promoter mutations and both immunohistochemistry and fluorescence in situ hybridization to identify… CONTINUE READING

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