Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia

@article{Liu2012ClinicalUA,
  title={Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia},
  author={Chengxi Liu and Jitesh D. Kawedia and Cheng Te Cheng and Dequing Pei and Christian A. Fernandez and Xiangjun Cai and Kristine R. Crews and Sue Creviston Kaste and John Carl Panetta and William Paul Bowman and S. C. Jeha and John Torsten Sandlund and Williams E Evans and C -H Pui and Mary V. Relling},
  journal={Leukemia},
  year={2012},
  volume={26},
  pages={2303-2309}
}
Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We studied allergic reactions and serum antibodies to E. coli asparaginase (Elspar) in 410 children treated on St. Jude Total XV protocol for acute lymphoblastic leukemia. Of 169 patients (41.2%) with clinical allergy, 147 (87.0%) were positive for anti-Elspar antibody. Of 241 patients without allergy, 89 (36.9%) had detectable antibody… CONTINUE READING
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Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia

C Liu, JD Kawedia, +12 authors MV Relling
  • 2012

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