Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients.

@article{Chin2011ClinicalUO,
  title={Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients.},
  author={Clifford C Chin and Ge Chen and Flavia Sequeria and Gerald T Berry and Stephanie L. Siehr and D. Bernstein and David C Rosenthal and Olaf Reinhartz and Dolly B. Tyan},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2011},
  volume={30 2},
  pages={158-63}
}
BACKGROUND Donor-specific antibodies (DSA) against human leukocyte antigens complicate transplantation with the potential for acute antibody-mediated rejection (AMR). Complement-fixing antibodies are required to initiate the complement cascade. Not all DSAs, however, can fix complement. METHODS A novel C1q assay was developed to detect the sub-set of immunoglobulin G (IgG) antibodies capable of fixing complement. Sera from 18 pediatric heart transplant patients were analyzed for DSAs using a… CONTINUE READING

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