Clinical use of creatine in neuromuscular and neurometabolic disorders.

@article{Tarnopolsky2007ClinicalUO,
  title={Clinical use of creatine in neuromuscular and neurometabolic disorders.},
  author={Mark A Tarnopolsky},
  journal={Sub-cellular biochemistry},
  year={2007},
  volume={46},
  pages={
          183-204
        }
}
Many of the neuromuscular (e.g., muscular dystrophy) and neurometabolic (e.g., mitochondrial cytopathies) disorders share similar final common pathways of cellular dysfunction that may be favorably influenced by creatine monohydrate (CrM) supplementation. Studies using the mdx model of Duchenne muscular dystrophy have found evidence of enhanced mitochondrial function, reduced intra-cellular calcium and improved performance with CrM supplementation. Clinical trials in patients with Duchenne and… CONTINUE READING
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