Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine.

@article{Kress2009ClinicalUO,
  title={Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine.},
  author={Hans Georg Kress},
  journal={European journal of pain},
  year={2009},
  volume={13 3},
  pages={219-30}
}
Buprenorphine was not used widely in clinical practice over many years, mainly due to analgesic potency and clinical safety concerns based on misinterpreted animal data. Contrary to previous concerns, however, no analgesic ceiling effect and no antagonism of combined pure mu-opioid receptor agonists is seen within the therapeutic dose range. In recent studies, buprenorphine could be effectively and safely combined with full mu-agonists, and switching between buprenorphine and another opioid… CONTINUE READING

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